Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid Muscle Inhibition
MEDICAL UNIV OF SOUTH CAROLINA CHARLESTON
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The sublaterodorsal SLD nucleus is hypothesized to induce muscle atonia during rapid eye movement REM sleep. This was tested by injecting channelrhodopsin into the SLD of 5 rats, followed by a series of behavioral tests. Results confirmed our ability to rapidly induce muscle atonia following optogenetic stimulation of the SLD, suggesting that activation of the SLD is sufficient to cause a REM atonia like state.
- Anatomy and Physiology