Accession Number:

ADA625406

Title:

Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid Muscle Inhibition

Descriptive Note:

Corporate Author:

MEDICAL UNIV OF SOUTH CAROLINA CHARLESTON

Report Date:

2015-09-01

Pagination or Media Count:

24.0

Abstract:

The sublaterodorsal SLD nucleus is hypothesized to induce muscle atonia during rapid eye movement REM sleep. This was tested by injecting channelrhodopsin into the SLD of 5 rats, followed by a series of behavioral tests. Results confirmed our ability to rapidly induce muscle atonia following optogenetic stimulation of the SLD, suggesting that activation of the SLD is sufficient to cause a REM atonia like state.

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE