Accession Number:

ADA625384

Title:

Bottom-up Assembly of Engineered Protein Fibers

Descriptive Note:

Final rept. 1 Oct 2011-30 Sep 2015

Corporate Author:

POLYTECHNIC UNIV BROOKLYN NY

Personal Author(s):

Report Date:

2015-02-15

Pagination or Media Count:

17.0

Abstract:

Inspired by natures approach to biomaterials synthesis, we employ a bottom up assembly of proteins to fabricate defined fibers that are robust and stable. We have decorated these protein fibers with bioorthogonal chemical moieties in the form of unnatural amino acids to achieve stability in fiber assembly and defined inorganic protein complexes with magnetic properties. The resulting set of proposed biopolymers bear tremendous impact in understanding the principles for designing highly robust protein fibers in general. Moreover, the coupling of inorganic materials with biomaterials provides a means for patterning magnetite crystals on assemblies.

Subject Categories:

  • Biochemistry
  • Polymer Chemistry
  • Biomedical Instrumentation and Bioengineering

Distribution Statement:

APPROVED FOR PUBLIC RELEASE