Accession Number:

ADA624939

Title:

Use of Topical PC-NSAIDs to Treat Burn Injury and Pain

Descriptive Note:

Annual rept. 5 Jul 2014-4 Jul 2015

Corporate Author:

TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON

Personal Author(s):

Report Date:

2015-08-01

Pagination or Media Count:

12.0

Abstract:

Studies in year one have shown that the rat dorsal burn wound model is appropriate for testing the analgesic and healing rate efficacy of test drugs. This model was used to test Indomethacin-PC Indo-PC, Indomethacin and appropriate controls when administered either topically or parenterally. The experimental drug Indo-PC showed significant analgesic efficacy over Indo alone at an early time point when the drugs were administered subcutaneously, and Indo-PC also tended to provide better analgesia than Indo alone after topical administration. No differences in healing rate were evident from any treatment. These studies support a rationale for continued development of Indo-PC for treatment of acute pain caused by 2nd degree burn wounds.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE