Accession Number:

ADA624585

Title:

Signal Propagation and Detection via Catalytically Immolative Biopolymer-Programmed Nanomaterials

Descriptive Note:

Final rept. 1 Aug 2011-31 Jul 2014

Corporate Author:

CALIFORNIA UNIV SAN DIEGO LA JOLLA

Personal Author(s):

Report Date:

2015-02-09

Pagination or Media Count:

21.0

Abstract:

Over the course of the funding of this proposal August, 2011 to March 2013 we endeavored to pioneer the use of selective biochemical reactions and interactions for the preparation and manipulation of nanomaterials. Such interactions, especially those caused by selective enzymatic reactions, are vastly underutilized in materials science in general. This is surprising, given the fact that selective enzymatic reactions are responsible for the formation of some of the most extraordinary examples of well-defined nanomaterials and dynamic processes known from the formation of virus capsids, to the repair and replication of genetic information in living systems. We believe such approaches will enable the preparation of ever more complex nanomaterials capable of adapting to their environment and responding to stimuli in an autonomous fashion yielding switches and changes in their properties, chemistry and function. One particular focus of this program has been an effort to directly incorporate nucleic acids into polymeric materials through polymerization of nucleic acid monomers , and the incorporation of peptides and sensing elements into responsive nanomaterials in general. With the completion of this grant we believe we have achieved this, and published on this data accordingly. Excitingly, the work has lead in many new directions and we continue to push forward and make progress in these arenas.

Subject Categories:

  • Biochemistry
  • Polymer Chemistry
  • Miscellaneous Materials
  • Atomic and Molecular Physics and Spectroscopy
  • Biomedical Instrumentation and Bioengineering

Distribution Statement:

APPROVED FOR PUBLIC RELEASE