Role of Complement in Red Cell Dysfunction in Trauma
Final rept. 1 Nov 2011-30 Nov 2013
BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
Pagination or Media Count:
Our preliminary data on RBC deformability, Ca influx and NO production suggest that the increased complement deposition on RBCs in patients with trauma may lead to the cytoskeletal changes in RBCs. This mechanism may retard the ability of RBCs to travel through capillaries and subsequently affect the delivery of O2 to the tissues. Thus understanding the pathophysiological relevance of complement activation and red cell dysfunction after trauma will provide a rationale to design pharmacological strategies that can prevent complement-RBC mediated post-traumatic mortality.
- Anatomy and Physiology
- Medicine and Medical Research