Accession Number:

ADA624508

Title:

Mapping the Vasculome for Biomarkers in TBI

Descriptive Note:

Final rept. 30 Sep 2012-29 Sep 2014

Corporate Author:

MASSACHUSETTS GENERAL HOSPITAL BOSTON

Personal Author(s):

Report Date:

2014-12-01

Pagination or Media Count:

14.0

Abstract:

Mild-to-moderate TBI is the signature injury of US military personnel. Thus, there is an urgent need to find biomarkers for mild-to-moderate TBI. In this proposal, our plan was to develop a vasculome database for TBI brain. By mapping the vasculome i.e. entire gene expression profile in blood vessels using mouse models of TBI, we will generate a comprehensive database that can be mined by the research community for potentially novel biomarkers of TBI. In this annual report, we describe our progress for the first year of our research, i.e. completion of all in vivo TBI mouse models, measurement of neurological deficits in all TBI mice, and the isolation of TBI microvessels and mRNA extraction.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE