Accession Number:

ADA624475

Title:

Endophenotypes of Dementia Associated with Traumatic Brain Injury in Retired Military Personnel

Descriptive Note:

Final rept. 30 Sep 2012-27 Mar 2015

Corporate Author:

NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO

Personal Author(s):

Report Date:

2015-06-01

Pagination or Media Count:

14.0

Abstract:

Our goal is to define the clinical phenotype of cognitive impairment in older veterans who have been exposed toTBI. Our hypothesis is that TBI in early to mid-life is associated with a clinical phenotype that has features distinguishable from AD. In the first year, we completed the screening survey portion of the study and found that over half of the veterans surveyed n298 had a history of head injury, with over 20 requiring hospitalization. Those with TBI were more likely to report mood, anxiety, substance use disorder, and PTSD symptoms over the course of their lifetime, have active PTSD symptoms, and have subjective memory complaints all p 0.05. A manuscript based on these results has been submitted to a peer-reviewed journal. Data collection for the cross-sectional study phase is finished n71 controls, n75 TBI. The main analysis is complete and a manuscript describing the clinical phenotype of TBI in older veterans is nearly ready for submission. Another manuscript, detailing the neuropsychological results, is in preparation. The results of this study show that older veterans with past TBI have a specific clinical and neuropsychological phenotype, which has relevance for future treatment.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Weapons Effects (Biological)

Distribution Statement:

APPROVED FOR PUBLIC RELEASE