Neurocognitive Effects of Radiotherapy
Annual rept. 1 Oct 2012-30 Sep 2013
TRUSTEES OF PENNSYLVANIA UNIV PHILADELPHIA PA
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This report describes continued work on the award Neurocognitive Effects of Radiotherapy , which examines the neurocognitive and imaging impact of proton therapy for patients will low grade glioma and base of skull meningioma. A total of 21 patients have been enrolled 8 patients in the skull base cohort 1 2 female photon and 6 2 male 4 female protons, 4 female and 1 male patient in the low grade gliomameningioma cohort 2 and 9 6 male, 3 female control patients. We continue to achieve continuous enrollment with 4 of the above 21 patients enrolled during the most recent quarter July, August, September 2013. All patients have completed a 4-5 hour neurocognitive testing assessment at baseline by Dr. Carol Armstrong. In addition, all patients have completed a 1 hour standard MRI as well as additional testing including diffuse tensor imaging DTI, perfusion and diffusion. The majority of patients have completed baseline and at least two additional time-points in regards to both neurocognitive testing and MRI. Although data are preliminary, neurocognitive results for 15 subjects 9 proton, 6 control indicate no indication of deterioration in procedural learning or complex attention from pre-proton baseline to 1.5 months after completing radiation based on the Serial Response Test and Audiovisual Attention Shift task, respectively. The Timing Function TF test indicates that patients may be less accurate in time perception than controls however, it also demonstrates a trend of recovery in this skill from pre-proton baseline to 1.5 months after radiation. All three of these tests are experimental and require validation in this particular setting. Based on these preliminary data, all three appear reliable, with the TF test appearing most sensitive for change over time in patients, while providing stable results in controls. Imaging analysis has been carried out independently from neurocognitive analysis.
- Medicine and Medical Research