Spinal Cord Repair with Engineered Nervous Tissue
Final rept. 30 Sep 2010-29 Jan 2014
PENNSYLVANIA UNIV PHILADELPHIA
Pagination or Media Count:
Spinal cord injury SCI exacts an enormous social and financial burden on society. As such, there has been considerable attention directed at finding treatment strategies, including development of tissue and cell transplant techniques. However, the current approaches do not adequately address the complexity of the injury site, such as lesion length and an environment that is usually non-permissive for axon regeneration. We have developed tissue engineered nerve grafts TENGs consisting of living dorsal root ganglia DRG and axons that can be stretch-grown to a length necessary to bridge extensive lesions. In current studies, we have optimized in vivo laminoplasty procedures, transplanted 5 mm-long stretch-grown constructs into a 5 mm-long lesion in the rat thoracic spinal cord, and have demonstrated survival of DRGs up to 6 weeks post-transplant. If successful, this approach will provide an alternative or additional means to repair large spinal lesions.
- Anatomy and Physiology
- Medicine and Medical Research