Divergent Effects of Dendritic Cells on Pancreatitis
Final rept. 15 Aug 2012-14 Aug 2015
NEW YORK UNIV NY
Pagination or Media Count:
Numbers dendritic cells DCs increased 100-fold in pancreata of mice with acute pancreatitis to account for nearly 15 of intrapancreatic leukocytes. Intrapancreatic DCs acquired a distinct immune phenotype in mice with acute pancreatitis they expressed higher levels of major histocompatibility complex II and CD86 and increased production of interleukin-6, MCP 1, and TNFa. DC over-expansion exacerbated disease. However, DCs were also required for pancreatic viability the exocrine pancreas died in mice that were depleted of DCs and challenged with caerulein or L-arginine. All mice with pancreatitis that were depleted of DCs died from acinar cell death within 4 days. These data suggest that DC have simultaneous paradoxical pro-inflammatory and protective effects in pancreatitis. Further investigations are warranted.
- Medicine and Medical Research