Mechanistic Links Between PARP, NAD, and Brain Inflammation After TBI
Annual rept. 25 Sep 2014-24 Sep 2015
NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO
Pagination or Media Count:
This project is a pre-clinical evaluation of the efficacy of veliparib and NAD as agents for suppressing inflammation and improving outcomes after traumatic brain injury. The animal models include pig and rat models of controlled cortical impact and blast injury. Work completed in this year 2 of 3 includes the large majority of the pig CCI and blast studies, and all rat veliparib animal surgeries. The behavioral analyses for these is completed, and the histological analyses are ongoing. Rat blast studies are ongoing. The studies using NAD as an anti-inflammatory agent have also been initiated. Results of the studies completed confirm that veliparib and NAD attenuate microglial activation after both blast and CCI. Veliparib improves outcome on some of the elevated plus maze and several aspects of the 5-choice reaction test when administered within 2 hours of injury. Analysis of long term 2-month survival is ongoing.
- Anatomy and Physiology
- Medicine and Medical Research