Accession Number:

ADA624276

Title:

Matrix Metalloproteinases as a Therapeutic Target to Improve Neurologic Recovery After Spinal Cord Injury

Descriptive Note:

Annual rept. 30 Sep 2013-29 Sep 2014

Corporate Author:

CALIFORNIA UNIV SAN FRANCISCO

Report Date:

2014-10-01

Pagination or Media Count:

70.0

Abstract:

We are evaluating efficacy of GM6001, a matrix metalloproteinase MMP inhibitor in a murine model of spinal cord injury UCSF and in dogs Texas A M, TAMU that sustain naturally occurring spinal cord injuries resulting from spontaneous intervertebral disk herniation IVDH. Scope These studies focus on efficacy of GM6001 in the context of an optimal therapeutic window and dependency on injury severity, using clinically relevant neurologic and urologic outcome measures.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE