Matrix Metalloproteinases as a Therapeutic Target to Improve Neurologic Recovery After Spinal Cord Injury
Annual rept. 30 Sep 2013-29 Sep 2014
CALIFORNIA UNIV SAN FRANCISCO
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We are evaluating efficacy of GM6001, a matrix metalloproteinase MMP inhibitor in a murine model of spinal cord injury UCSF and in dogs Texas A M, TAMU that sustain naturally occurring spinal cord injuries resulting from spontaneous intervertebral disk herniation IVDH. Scope These studies focus on efficacy of GM6001 in the context of an optimal therapeutic window and dependency on injury severity, using clinically relevant neurologic and urologic outcome measures.
- Medicine and Medical Research