A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury
Annual rept. 1 Sep 2013-31 Aug 2014
CASE WESTERN RESERVE UNIV CLEVELAND OH
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A small, lightweight microdevice has been developed for activity-dependent stimulation ADS and successfully tested for functionality in both anesthetized and ambulatory rats. Further, in semi-chronic experiments in rats with traumatic brain injury TBI using this microdevice, an unprecedented, potent effect of ADS on motor performance has been demonstrated, as compared to control rats injured but no microdevice and open-loop stimulation OLS rats. Specifically, OLS does result in some recovery after injury, but ADS is significantly more efficacious, resulting in recovery to normal ranges of performance within 2 weeks after injury. In the final stage of this funding period, we will prepare to extend these findings to non-human primates as we finalize a the optimal parameters for the primate TBI model and b the design and construction of the primate microdevice.
- Anatomy and Physiology
- Medicine and Medical Research
- Biomedical Instrumentation and Bioengineering