Identification of Prostate Cancer-Specific Circular RNAs
Annual rept. 15 Sep 2014-14 Sep 2015
MISSISSIPPI UNIV MEDICAL CENTER JACKSON
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The major goal of this application is to determine whether newly identified circular RNAs can serve as novel biomarkers for prostate cancer diagnosis and prognosis. There are three specific aims. First, we will determine whether prostate cancer cells display different patterns of circular RNAs from those of normal tissue. Then, we will determine whether differential expression of circular RNAs can also be detected in cell culture models because we can easily manipulate the levels of circular RNAs in cell culture so that we are able to study their functions. Finally, we will determine whether circular RNAs are differentially expressed in bloodserum samples from healthy individuals and prostate cancer patients.
- Anatomy and Physiology
- Medicine and Medical Research