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Effects of Tobacco Smoke (TS) on Growth of Clear Cell Renal Cell Carcinoma (ccRCC)

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Annual rept. 30 Sep 2014-29 Sep 2015

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Clear cell renal cell carcinoma ccRCC is the most common malignant form of renal cancer that occurs more frequently in males than in females 1 . Tobacco smoking TS, obesity, hypertension, and age are established risk factors for ccRCC development 1 . Despite the well published and strongly documented association between TS and ccRCC, the genetic and signaling landscape of effects of TS on ccRCC is very little understood. The Cancer Genome Atlas TCGA database and the seminal report from The Cancer Genome Atlas Research Network, published in July 2013 in Nature, established the genetic landscape of ccRCC but did not focus on the relationship of ccRCC with smoking. This is a gap in our understanding of this important risk factor and genetic cause of ccRCC. Here we hypothesize that TS-derived oncogenic metabolites cause distinctive genomic and signaling changes in kidneytumor tissues and promote ccRCC tumor growth. Because of a high prevalence of smoking in active military personnel and veterans, the male military population over the age of 40 years has an overall 5- to 6-fold increased incidence of ccRCC compared to the general population Defense Medical Epidemiology Database, DMED, 1995-2004. The main purpose of the work is to collect and genetically analyze primary ccRCC tumors from a cohort of male veteran patients who are heavy smokers.

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  • Anatomy and Physiology
  • Medicine and Medical Research
  • Military Forces and Organizations

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