Host Genes and Resistance/Sensitivity to Military Priority Pathogens
Annual rept. 1 Jun 2011-30 Jun 2012
TENNESSEE UNIV MEMPHIS HEALTH SCIENCE CENTER
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This report provides data from our study of differential susceptibility to DoD priority pathogens Francisella tularensis FT, Burkholderia pseudomallei Bp, Acinetobacter baumannii Ab, Leishmania major Lm, SARS, H5Ni avian influenza using BXD recombinant inbred mice. We have identified 38 phenotypes that may that may lead to differential immune responsiveness of C57BL6 B6 vs DBA2 D2 mice following Ab infection. Data from the Bp study indicates that survival of acute pneumonic Burkholderia infection is a complex trait that may involve at least 3 different loci. FT studies have shown that there are differences in innate immune responses to pneumonic FT infection between B6 and D2 mice. The SARS study found that D2 mice are more susceptible to MA15 virus than B6 mice. The mouse genomics core continues to generate datasets spleen, lung, T-cells, etc from BXD strains, which are available on GeneNetwork. The bioinformatics core has implemented a method for performing Bayesian network analysis of biological data, such as responses to pathogen infection and other biological processes. Studies with all the pathogens are ongoing to identify host genespathways that are involved in disease process.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research