Global Positioning Systems (GPS) Technology to Study Vector-Pathogen-Host Interactions
Annual rept. 26 Oct 2013-26 Oct 2014
WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD
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The objective of this project is to examine the evolutionary consequences of introducing a tetravalent live-attenuated dengue virus vaccine into children in Northern Thailand on naturally occurring endemic wild-type dengue virus. Dengue is the most common arbovirus causing human disease in subtropical and tropical regions of the world and estimated that over 50 million infections occur each year and over 20,000 deaths. In this grant, an interdisciplinary team of university and military investigators have conducted coordinated studies to determine the effect vaccination with a candidate tetravalent vaccine will have on genetic changes on wild-type dengue virus and how these changes will determine risk for severe dengue and serotype-specific dengue virus transmission. Studies are being conducted in Kamphaeng Phet Province, Northern Thailand, to isolate wild-type dengue virus and examine genetic diversity in the population, in hospitalized children with severe dengue illness and cluster investigation of their neighborhoods, and by using sophisticated Global Positioning Systems GPS technology of isolated viruses and genetic characterization, spatial and temporal analysis are being performed in detail. This study is a unique opportunity to study the evolutionary consequences of this vaccine on wild-type dengue virus with findings that will have long-term impact on the design of future dengue vaccines and conduct of dengue vaccine efficacy trials.
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