Accession Number:

ADA624177

Title:

Treating Combat Hearing Loss with Atoh1 Gene Therapy

Descriptive Note:

Final rept. 1 Oct 2010-31 Mar 2015

Corporate Author:

BAYLOR COLL OF MEDICINE HOUSTON TX

Personal Author(s):

Report Date:

2015-06-01

Pagination or Media Count:

52.0

Abstract:

The goal of the project is to test experimental therapies for hearing loss in transgenic mouse models. We have identified a list of targets of the Atoh1 transcription factor which is a key to regenerating hair cells. We have shown that another candidate pathway, the Notch signaling pathway, is no longer active in the mature animal, and thus is not a viable therapeutic target for hearing loss. We have also generated the means to activate Atoh1 and a supporting factor, Gfi1, in deafened mice to promote hair cell regeneration.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Anatomy and Physiology
  • Medicine and Medical Research
  • Military Forces and Organizations

Distribution Statement:

APPROVED FOR PUBLIC RELEASE