Accession Number:

ADA624152

Title:

Identification of Biomarkers Associated with the Healing of Chronic Wounds. Addendum

Descriptive Note:

Final rept. 1 Jan 2008-31 May 2009

Corporate Author:

DAEMEN COLL AMHERST NY

Personal Author(s):

Report Date:

2009-06-01

Pagination or Media Count:

20.0

Abstract:

It is the objective of this study to identify the biomarkers associated with the earliest stages of healing in chronic wounds. The findings of this study are intended to facilitate the development a diagnostic tool, which could be used to evaluate the healing process. Samples have been collected from interior and peripheral wound sites over 6 weeks from 50 subjects thus far and analyzed using 2D Page, iTRAQTM, and antibody arrays. Different proteins have been identified in healed versus chronic wounds and in different locations within the wounds. The correlation of wound biochemistry, clinical appearance, and clinical outcome is critical to the understanding of pressure ulcer healing. These findings will aid in the development of criteria for evaluating the healing process and response to treatment.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE