Endophenotypes of Dementia Associated with Traumatic Brain Injury in Retired Military Personnel
Annual rept. 30 Sep 2013-29 Sep 2014
NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO
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Our goal is to define the clinical phenotype of cognitive impairment and dementia in older veterans who have been exposed to TBI. Our hypothesis is that TBI in early to mid-life is associated with a dementia phenotype that has features distinguishable from AD. In the first year, we completed the screening survey portion of the study and found that over half of the veterans surveyed n298 had a history of head injury, with over 20 requiring hospitalization. Those with TBI were more likely to report mood, anxiety, substance use disorder, and PTSD symptoms over the course of their lifetime, have active PTSD symptoms, and have subjective memory complaints all p 0.05. A manuscript based on these results has been submitted to a pepeer-viewed journal. Data collection for the cross-sectional study phase has recently been completed. Preliminary results, presented in an abstract, showed that executive function may be decreased in participants with TBI history compared to controls. We will soon begin analyzing the data from the full study 73 participants with TBI history and 70 controls. The results will determine if a clinical phenotype of dementia in individuals with TBI exists, which has relevance for future treatment.
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