Needle Acupuncture for Substance Use Disorders: A Systematic Review
RAND NATIONAL DEFENSE RESEARCH INST SANTA MONICA CA
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This systematic review synthesized evidence from trials of needle acupuncture to provide estimates of the effectiveness of needle acupuncture for substance use disorders PROSPERO record CRD42015016040. In November 2014, we searched PubMed, PsycINFO, CINAHL, AMED, CENTRAL MANTIS, and Embase, as well as bibliographies of existing systematic reviews and included studies, to identify English-language reports of randomized controlled trials RCTs testing the efficacy and safety of needle acupuncture--used adjunctively or as monotherapy--to treat adults diagnosed with alcohol, opioid, stimulant, andor cannabis use disorder. Two independent reviewers screened identified literature using predetermined eligibility criteria, abstracted studylevel information, and assessed the methodological quality of included studies. Outcomes of interest included relapse, quantity and frequency of substance use, withdrawal symptoms treatment dropout, functional status and quality of life, and adverse events. When possible, metaanalyses and meta-regressions were conducted using the Hartung-Knapp-Sidik-Jonkman method for random-effects models. Quality of evidence was assessed using the GRADE approach. Forty-one studies reported in 48 publications with 5,227 participants were included. When the data were pooled across studies, no significant effects of acupuncture as adjunctive or monotherapy versus any comparator versus any comparator were observed at postintervention for relapse SMD -0.12 95 CI -0.46 to 0.22 10 RCTs, frequency of substance use SMD -0.27 CI -2.67 to 2.13 2 RCTs, quantity of substance use SMD 0.01 CI -0.40 to 0.43 3 RCTs, or treatment dropout OR 0.82 CI 0.63 to 1.09 22 RCTs.
- Medicine and Medical Research