Accession Number:

ADA623488

Title:

A Model of Medical Countermeasures for Vesicant Exposure

Descriptive Note:

Technical rept. 15 Apr 2010-14 Apr 2013

Corporate Author:

APPLIED RESEARCH ASSOCIATES INC ARLINGTON VA

Report Date:

2015-10-01

Pagination or Media Count:

117.0

Abstract:

This paper describes a toxicokineticdynamic model of percutaneous exposure to several vesicants. The model also predicts the efficacy of proposed medical countermeasures via a pharmacokineticdynamic model of scavenger, cell-cycle inhibitor, PARP inhibitor, protease inhibitor, and anti-inflammatory treatment regimens.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE