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The Effects of Hemostatic Agents and Hypothermia Control in a Porcine Model

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Final rept. 1 Aug 2009-31 Jul 2014

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Purpose The primary purposes of this study were to determine the effectiveness of QuikClot Combat Gauze QCG and BleedArrest in a normovolemic model. In addition, the purposes were to investigate the effectiveness of QCG in a hemodiluted and resuscitated model in a hypothermic model and movement model. Design Studies were prospective, experimental design. Methods Swine were randomly assigned to experimental groups normovolemic resuscitated hemodiluted after bleed increased systolic blood pressure hypothermic or to a control group for each of the experimental groups. To simulate a trauma injury, the investigators generated a complex groin injury with transection of the femoral artery and vein in all pigs. After 1 minute of uncontrolled hemorrhage, the hemostatic agent was placed into the wound followed by standard wound packing. The control group underwent the same procedures with the exception of the hemostatic agent. In all groups, 5 minutes of direct manual pressure was applied to the wound followed by a standard pressure dressing. After 30 minutes, dressings were removed, and the amount of bleeding was determined. In the case of hemodilution, up to 5 liters of fluid were administered after hemostatis in the case of prior hemodilution, 30 pigs blood volume was exsanguinated, and a 31 ratio was administered in the case of hypothermia, a temperature less than 36 degrees C was achieved and in the case of movements, the number of extremity movements were counted before rebleeding occurred. Sample Yorkshire swine. Analysis MANOVA was used. Findings In all the studies normovolemic hemodiluted resuscitated hypothermic and manipulation of systolic blood pressure, and movement of extremities, QCG was effective in hemorrhage control p less than 0.05.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Medical Facilities, Equipment and Supplies

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