Accession Number:

ADA622970

Title:

A Multi-Scale Modeling and Experimental Program for the Dynamic Mechanical Response of Tissue

Descriptive Note:

Final rept. 1 Aug 2009-31 Jul 2014

Corporate Author:

ILLINOIS INST OF TECH CHICAGO

Report Date:

2014-12-09

Pagination or Media Count:

24.0

Abstract:

We study the mechanical properties of collagen, which is the most prevalent protein in humans, and largely responsible for the mechanical properties of tissue. We use both a multiscale modeling approach, and experiments to examine the theoretical results. The atomistic structure of collagen is determined by Xray diffraction, which provides the starting point for atomistic simulations. These simulations are then used to predict the modulus of collagen fibrils. The bending modulus of fibrils is finally measured by using optical tweezers.

Subject Categories:

  • Biochemistry
  • Mechanics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE