Accession Number:

ADA622684

Title:

Characterizing and Targeting Replication Stress Response Defects in Breast Cancer

Descriptive Note:

Annual rept. 15 Jul 2014-14 Jul 2015

Corporate Author:

M D ANDERSON CANCER CENTER HOUSTON TX

Report Date:

2015-08-01

Pagination or Media Count:

9.0

Abstract:

During the fifth year of this project, we have successfully verified AXL protein as a reliable membrane marker for replication stress response defect RSRD breast cancer cells and we demonstrated the potential to use isotope-labeled anti-human AXL antibody to detect RSRD breast cancer cells in vivo. In addition, we have clearly demonstrated the in vivo therapeutic effects of MEK inhibitor, AZD6244, and ERK inhibitor, SCH772984 on targeting RSRD breast cancer cells in two xenograft mouse models

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Biology
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE