Accession Number:

ADA622474

Title:

Francisella DnaK Inhibits Tissue-Nonspecific Alkaline Phosphatase

Descriptive Note:

Journal article

Corporate Author:

ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX

Report Date:

2012-10-26

Pagination or Media Count:

11.0

Abstract:

Pulmonary Franciscella infection resulted in reduction of plasma alkaline phosphatase activity. Franciscella heat shock protein DnaK binds to alkaline phosphatase thus reducing enzymatic activity, A Franciscella protein component responsible for alkaline phosphatase inhibition was identified. We present a novel mechanism used by a bacterial pathogen to evade the hosts defense.

Subject Categories:

  • Biochemistry
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE