Molecular Innovations Toward Theranostics of Aggressive Prostate Cancer
Annual rerpt. 1 Sep 2013-31 Aug 2014
TEXAS CHRISTIAN UNIV FORT WORTH
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The efforts during this period include 1 the exploration of dendrimers that provide water solubility in the presence of hydrophobic peptides a limitation encountered in the previous period, 2 the production of dendrimers with a DOTA-chelating ligand that can host the imaging agent, and 3 production of candidate theranostic dendrimer-peptide platforms for the evaluation of biological activity. A new conjugation strategy has been developed and shown to be useful for making the proposed multivalent conjugates. Samples continue to be submitted to our collaborators for biological evaluation.
- Medicine and Medical Research
- Physical Chemistry