Accession Number:

ADA622389

Title:

Molecular Innovations Toward Theranostics of Aggressive Prostate Cancer

Descriptive Note:

Annual rerpt. 1 Sep 2013-31 Aug 2014

Corporate Author:

TEXAS CHRISTIAN UNIV FORT WORTH

Personal Author(s):

Report Date:

2014-09-01

Pagination or Media Count:

15.0

Abstract:

The efforts during this period include 1 the exploration of dendrimers that provide water solubility in the presence of hydrophobic peptides a limitation encountered in the previous period, 2 the production of dendrimers with a DOTA-chelating ligand that can host the imaging agent, and 3 production of candidate theranostic dendrimer-peptide platforms for the evaluation of biological activity. A new conjugation strategy has been developed and shown to be useful for making the proposed multivalent conjugates. Samples continue to be submitted to our collaborators for biological evaluation.

Subject Categories:

  • Medicine and Medical Research
  • Physical Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE