Accession Number:

ADA622386

Title:

Maximizing PTH Anabolic Osteoporosis Therapy

Descriptive Note:

Annual rept. 15 Aug 2014-14 Aug 2015

Corporate Author:

INDIANA UNIV INDIANAPOLIS

Personal Author(s):

Report Date:

2015-09-01

Pagination or Media Count:

167.0

Abstract:

The subject of this research is the need for improved osteoporosis therapies. The purpose of this study is to test the efficacy of parathyroid hormone PTH mono - therapy and PTH anti-catabolic combination therapies on Nmp4 -- and wild type WT mice . We have previously determined that Nmp4 represses the response of bone to osteoanabolics 1-3. The scope of th is research comprises the following specific aims i ii to determine the impact of Nmp4 on the efficacy of PTH mono - and combination therapies with bisphosphonates and the selective estrogen receptor modulator SERM raloxifene in ovariectomized ovx mice iii to determine the cell type specific contributions to the enhanced response of the Nmp4 -- mouse to these osteoporosis therapies.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE