Why Do Only Some Women Develop Post-Menopausal Osteoporosis?
Final rept. 1 Sep 2013-28 Feb 2015
MOUNT SINAI HOSPITAL TORONTO (ONTARIO)
Pagination or Media Count:
The proposed project addresses a novel and potentially important mechanism of osteoporosis which may determine which women suffer the disease. Confirmation and understanding of this mechanism will lead to new prediction methods and treatments for osteoporosis patients and greatly improve the lives of affected civilian, military and veteran populations. At the onset of menopause, lack of estrogen and other sex steroids results in increased bone turnover and net bone loss. Fortunately, only 25-30 of post-menopausal women will develop vertebral fractures the hallmark of post-menopausal osteoporosis because of differences in the amount of bone lost. This proposal presents a novel theory to explain why only some women get osteoporotic fractures and proposes a first experiment to test this theory. The theory suggests a critical link between the estrogen loss, the advanced glycation endproduct AGE content of the bone, and signaling via the receptor for advanced glycation endproducts RAGE and that the combination of these three components determines the extent of bone loss post menopause. The broadly accepted ovariectomized female rat will be used to model post menopausal bone loss. A special diet will induce advanced glycation endproduct formation.
- Medicine and Medical Research