Accession Number:

ADA621840

Title:

Micro/nano-particles and Cells: Manipulation, Transport, and Self-assembly

Descriptive Note:

Final rept. 1 Aug 2010-31 Jul 2014

Corporate Author:

OHIO STATE UNIV COLUMBUS

Personal Author(s):

• Sooryakumar, R.

Report Date:

2014-10-23

Pagination or Media Count:

22.0

Abstract:

Technologies that control nano- and micron-sized inert as well as biological materials are crucial to realizing engineered systems that can assemble, transport, and manipulate objects at these length scales. Two principles, a the domain wall structure of patterned magnetic structures and b the superparamagnetic properties of nanoparticles, were used to apply directed forces that maneuver, transport, sort and configure these tiny entities on a platform. Convenient, remotely activated, changes to the local energy landscape of the platform that were developed underlie the ability to, a generate high 10,000 Tm local field gradients, b selectively apply femto- to pico-Newton scale forces to objects with designed magnetic signatures and c direct these forces along desired pathways. A broad range of problems, both fundamental and applied, also benefited from control over the stochastic Brownian trajectories of trap-confined micro- and nano-particles. The projects ranged from activation of soft confinement barriers through creation of novel time-orbiting magnetic potentials that provide a new framework to stabilize intricate and design-specific behavior of interacting magnetic dipoles, formation of magnetic colloidal rotor pumps actuated within microfluidic channels, and the high-throughput transfection of genes into living cells for screening cellular heterogeneity.

Descriptors:

• *CELLS(BIOLOGY)
• *MAGNETIC DIPOLES
• *MAGNETIC TAPE TRANSPORT
• *NANOPARTICLES
• BIOLOGICAL DETECTION
• BROWNIAN MOTION
• CARRIER MOBILITY
• COLLOIDS
• CONFINEMENT(GENERAL)
• DIAGNOSIS(MEDICINE)
• DOMAIN WALLS
• GENE EXPRESSION
• GRADIENTS
• HETEROGENEITY
• INTERACTIONS
• MAGNETIC SIGNATURES
• MOLECULAR ISOMERISM
• SELF ASSEMBLED MONOLAYERS
• STABILIZATION
• STOCHASTIC PROCESSES
• SYSTEMS ENGINEERING
• THROUGHPUT
• TRAJECTORIES

Subject Categories:

• Genetic Engineering and Molecular Biology
• Physical Chemistry
• Electricity and Magnetism
• Solid State Physics
• Biomedical Instrumentation and Bioengineering

Distribution Statement:

APPROVED FOR PUBLIC RELEASE