Accession Number:

ADA621824

Title:

Targeting Androgen Receptor by Lysosomal Degradation in Prostate Cancer

Descriptive Note:

Final rept. 1 Sep 2013-31 Aug 2015

Corporate Author:

TEXAS UNIV HEALTH SCIENCE CENTER AT SAN ANTONIO

Personal Author(s):

• Shiio, Yuzuru

Report Date:

2015-11-01

Pagination or Media Count:

19.0

Abstract:

Androgen receptor AR plays a critical role in the progression of prostate cancer. This project is directed towards testing the feasibility of targeting AR for lysosomal degradation. We have demonstrated that AR can indeed be targeted for degradation by stimulating the TFEB-lysosome degradation pathway either by increasing the TFEB levels or by activating TFEB using mTORC1 kinase inhibitor, torin 1. Additionally, we determined that the same approach can be used to target the EWS-Fli-1 oncoprotein for degradation.

Descriptors:

• *ANDROGENS
• *PROSTATE CANCER
• *RECEPTOR SITES(PHYSIOLOGY)
• INHIBITION
• PHOSPHORUS TRANSFERASES
• PROTEINS
• THERAPY

Subject Categories:

• Biochemistry
• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE