Accession Number:

ADA621822

Title:

Defining Translational Reprogramming in Tuberous Sclerosis Complex

Descriptive Note:

Annual rept. 1 Jul 2014-30 Jun 2015

Corporate Author:

CORNELL UNIV ITHACA NY

Personal Author(s):

• Qian, Shu-Bing

Report Date:

2015-07-01

Pagination or Media Count:

38.0

Abstract:

Tuberous sclerosis complex TSC is an autosomal dominant disease characterized by benign tumors in various tissues. The genes mutated in this disease, TSC1 and TSC2, encode tumor suppressors that are associated in a complex. The TSC12 complex, through its Rheb-GAP activity, is a critical negative regulator of mTORC1 under physiological conditions. Activation of mTORC1 positively stimulates cap-dependent mRNA translation via its downstream substrates S6K and 4E-BP. In our previous study, we demonstrated that TSC-mTORC1 signaling regulates the balance between cap-dependent and cap-independent translation. In this project, we aim to 1 Dissect the molecular linkage between mTORC1 and protein homeostasis 2 Define the role of mTORC1 in ribosome dynamics and translational re-programming.

Descriptors:

• *HOMEOSTASIS
• *PROTEINS
• *RIBOSOMES
• *TRANSCRIPTION(GENETICS)
• GENES
• MUTATIONS
• NEOPLASMS
• QUALITY CONTROL
• RIBONUCLEIC ACIDS

Subject Categories:

• Biochemistry
• Genetic Engineering and Molecular Biology
• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE