Accession Number:

ADA621821

Title:

Stem Cell Therapy for Healing Wounded Skin and Soft Tissues

Descriptive Note:

Final rept. 15 Jun 2010-14 Dec 2013

Corporate Author:

GENEVA FOUNDATION TACOMA WA

Personal Author(s):

• Leung, Kai P.
• Hong, S. K.
• Mustoe, T. A.
• Hale, R. G.

Report Date:

2014-03-01

Pagination or Media Count:

57.0

Abstract:

Exogenously applied stem cells can integrate into wounds, and if properly directed to regenerate tissue rather than to rapidly restore the barrier function, should be able to regenerate tissue for improved wound healing. We hypothesize that when applied topically to wounds, adult, adipose-derived mesenchymal stem cells that are directed toward tissue regeneration can reduce inflammation, increase angiogenesis, reduce scarring, and improve the restoration of skin functions. The goal of the proposed research is to define the function of stem cells alone or in atrix to promote healing by regeneration to improve wound repair outcomes.

Descriptors:

• *STEM CELLS
• CYTOKINES
• HEALING
• REGENERATION(PHYSIOLOGY)
• SOFT TISSUES
• THERAPY
• WOUNDS AND INJURIES

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE