Accession Number:

ADA621778

Title:

Synthetic Platelets: Intravenous Infusible Nanoparticles to Promote Hemostasis and Survival Following Liver Injury in Swine

Descriptive Note:

Final rept. 13 Aug 2012-12 Aug 2014

Corporate Author:

NAVAL MEDICAL LOGISTICS COMMAND FORT DETRICK MD

Personal Author(s):

• Lavik, Erin

Report Date:

2014-08-12

Pagination or Media Count:

21.0

Abstract:

Explosions account for 79 of combat related injuries and involve multiple organs and internal bleeding, Pressure dressings and absorbent materials e.g. Quik-clot are effective but are limited to compressible and exposed wounds. There is a need for treatment for internal bleeding. Synthetic platelets were developed based on functionalized nanoparticles that halve bleeding in a rat major femoral artery injury following intravenous administration. The synthetic platelets are safe and stable at room temperature. They halt bleeding significantly faster than other treatments including recombinant factor VIla. This proposal tested these synthetic platelets in a large animal model of trauma that mimics human trauma A swine liver injury model was used to determine the safety, efficacy and dosing of the synthetic platelets. This model was developed to mimic non-compressible injuries sustained by military personnel and permits direct comparison to other hemostatic interventional studies. It was found that by carefully engineering the particles, one could stop bleeding without triggering complications.

Descriptors:

• *BLOOD PLATELETS
• *HEMORRHAGE
• *NANOMEDICINE
• *SYNTHETIC BIOLOGY
• COMPARISON
• FEMORAL ARTERIES
• LIVER
• NANOPARTICLES
• SWINE
• WOUNDS AND INJURIES

Subject Categories:

• Biochemistry
• Anatomy and Physiology
• Medicine and Medical Research
• Miscellaneous Materials

Distribution Statement:

APPROVED FOR PUBLIC RELEASE