Accession Number:

ADA621769

Title:

Targeted Approach to Overcoming Treatment Resistance in Advanced Prostate Cancer

Descriptive Note:

Final addendum rept. 1 Jul 2014-30 Jun 2015

Corporate Author:

GEORGIA SOUTHERN UNIV STATESBORO

Personal Author(s):

Report Date:

2015-09-01

Pagination or Media Count:

41.0

Abstract:

The purpose of this project is to determine if rescinnamine is effective against prostate cancer and treatment resistance. We determined that rescinnamine is less effective against prostate cancer than against other cancer types, making it less ideal to follow. In addition, the hypotensive activity of rescinnamine was dose-inhibitive in animal studies. We therefore pursued a combination of computational modeling, chemical synthesis and in vitro testing to identify analogs with higher efficacy and less toxicity. Initial results identified a small number of compounds, some of them entirely novel, that should be followed up on in subsequent studies.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research
  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE