Accession Number:

ADA621683

Title:

Probing Tumor Microenvironment With In Vivo Phage Display

Descriptive Note:

Final rept. 1 Jul 2012-30 Jun 2014

Corporate Author:

SANFORD-BURNHAM MEDICAL RESEARCH INST LA JOLLA CA

Personal Author(s):

• Sugahara, Kazuki

Report Date:

2014-10-01

Pagination or Media Count:

12.0

Abstract:

We have performed multiple phage screens in search for carcinoma-associated fibroblast CAF-targeting peptides utilizing the tumor-penetrating phage display technology combined with next generation phage DNA sequencing. We have identified at least 4 potentially novel CAFstroma-targeting peptides. One of the peptides, CIS, homed to breast tumor stroma in two mouse models, and the homing was significantly enhanced by iRGD co-injection.

Descriptors:

• *BREAST CANCER
• *MACROPHAGES
• *METASTASIS
• *PEPTIDES
• *RECEPTOR SITES(PHYSIOLOGY)
• ANGIOGENESIS
• CLINICAL MEDICINE
• DEOXYRIBONUCLEIC ACIDS
• FIBROBLASTS
• GENE EXPRESSION
• IN VITRO ANALYSIS
• IN VIVO ANALYSIS
• MICE
• MICROSCOPY
• MOLECULAR DYNAMICS
• NEOPLASMS
• OPTIMIZATION
• PATHOPHYSIOLOGY
• PROTEINS
• RESPONSE(BIOLOGY)
• STEM CELLS
• TARGETING
• THERAPY
• TISSUES(BIOLOGY)

Subject Categories:

• Biochemistry
• Anatomy and Physiology
• Medicine and Medical Research
• Biomedical Instrumentation and Bioengineering

Distribution Statement:

APPROVED FOR PUBLIC RELEASE