Accession Number:

ADA621683

Title:

Probing Tumor Microenvironment With In Vivo Phage Display

Descriptive Note:

Final rept. 1 Jul 2012-30 Jun 2014

Corporate Author:

SANFORD-BURNHAM MEDICAL RESEARCH INST LA JOLLA CA

Personal Author(s):

Report Date:

2014-10-01

Pagination or Media Count:

12.0

Abstract:

We have performed multiple phage screens in search for carcinoma-associated fibroblast CAF-targeting peptides utilizing the tumor-penetrating phage display technology combined with next generation phage DNA sequencing. We have identified at least 4 potentially novel CAFstroma-targeting peptides. One of the peptides, CIS, homed to breast tumor stroma in two mouse models, and the homing was significantly enhanced by iRGD co-injection.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research
  • Biomedical Instrumentation and Bioengineering

Distribution Statement:

APPROVED FOR PUBLIC RELEASE