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Regulation of Breast Cancer Stem Cells by Tissue Rigidity
Annual rept. 1 Jun 2014-31 May 2015
CALIFORNIA UNIV SAN DIEGO LA JOLLA
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The presence of a fibrotic focus in breast tumors is associated with a 10-50-fold increase in tissue stiffness and correlates with distant metastasis and poor outcome. Recent studies indicate that increasing tissue rigidity promotes breast cancer progression, however the underlying molecular mechanism is largely unknown. Breast cancer stem cells have both long-term self-renewal capacity and the ability to initiate tumors. In this proposal, we hypothesize that tissue rigidity regulates breast cancer stem cell properties and function, therefore assisting breast tumor development and promoting chemoresistance.
APPROVED FOR PUBLIC RELEASE