Accession Number:

ADA621622

Title:

Regulation of Breast Cancer Stem Cells by Tissue Rigidity

Descriptive Note:

Annual rept. 1 Jun 2014-31 May 2015

Corporate Author:

CALIFORNIA UNIV SAN DIEGO LA JOLLA

Personal Author(s):

• Engler, Adam J.
• Yang, Jing
• Fattet, Laurent
• Ondeck, Matthew

Report Date:

2015-06-01

Pagination or Media Count:

47.0

Abstract:

The presence of a fibrotic focus in breast tumors is associated with a 10-50-fold increase in tissue stiffness and correlates with distant metastasis and poor outcome. Recent studies indicate that increasing tissue rigidity promotes breast cancer progression, however the underlying molecular mechanism is largely unknown. Breast cancer stem cells have both long-term self-renewal capacity and the ability to initiate tumors. In this proposal, we hypothesize that tissue rigidity regulates breast cancer stem cell properties and function, therefore assisting breast tumor development and promoting chemoresistance.

Descriptors:

• *BREAST CANCER
• *RIGIDITY
• *SOFT TISSUES
• ASSAYING
• BIOLOGICAL DETECTION
• CHEMOTHERAPY
• CLINICAL MEDICINE
• CULTURES(BIOLOGY)
• EPITHELIUM
• GELS
• GENE EXPRESSION
• GROWTH(PHYSIOLOGY)
• MAMMARY GLANDS
• METASTASIS
• MICE
• MOLECULAR DYNAMICS
• NEOPLASMS
• PATHOPHYSIOLOGY
• PROTEINS
• RECEPTOR SITES(PHYSIOLOGY)
• RESISTANCE(BIOLOGY)
• RESPONSE(BIOLOGY)
• STEM CELLS
• STIFFNESS

Subject Categories:

• Genetic Engineering and Molecular Biology
• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE