Accession Number:

ADA621610

Title:

Virus Directed Assembly of Peptide Receptor Surfaces for Diverse Sensing Platforms and Applications

Descriptive Note:

Final rept. 1 May 2011-30 Apr 2014

Corporate Author:

MARYLAND UNIV COLLEGE PARK

Personal Author(s):

• Culver, James
• Ghodssi, Reza

Report Date:

2014-07-29

Pagination or Media Count:

15.0

Abstract:

The goal of this study has been to develop Tobacco mosaic virus TMV and its derived virus-like-particle VLP as a universal platform for the assembly, display and integration of receptor layers onto sensitive and robust transducer systems for biological and chemical detections. Unique features of this system include its genetic programmability, self-assembly, multivalent display capabilities and ability to be integrated with a range of transducer surfaces, including chip based ELISA, optical disk resonators, impedance electrodes and square wave electrochemical platforms. Combined these investigations have provided the basic knowledge needed to develop highly flexible and cost-effective receptor layers that are compatible with a range of target molecules and can be easily integrated within highly sensitive micro- and nano-system sensing platforms.

Descriptors:

• *BIOLOGICAL DETECTION
• *CHEMICAL DETECTION
• *NANOTECHNOLOGY
• *PEPTIDES
• *VIRUSES
• ELECTROCHEMISTRY
• ELECTRODES
• LAYERS
• MOLECULES
• RESONATORS
• SURFACES
• TRANSDUCERS

Subject Categories:

• Biochemistry
• Microbiology
• Electrical and Electronic Equipment
• Miscellaneous Detection and Detectors

Distribution Statement:

APPROVED FOR PUBLIC RELEASE