Accession Number:

ADA621480

Title:

Early Identification of Molecular Predictors of Heterotopic Ossification Following Extremity Blast Injury with a Biomarker Assay

Descriptive Note:

Annual rept. 30 Sep 2013-29 Sep 2014

Corporate Author:

HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE BETHESDA MD

Personal Author(s):

• Nesti, Leon J.

Report Date:

2014-10-01

Pagination or Media Count:

5.0

Abstract:

Following a traumatic orthopaedic injury, the affected muscle tissue is susceptible to a disease known as heterotopic ossification HO, which is characterized by the formation of bone in the soft tissue. This disease is especially common in soldiers that have sustained severe injuries during military operations. The current studies are directed at identifying early- appearing biomarkers in the animal model that predict the occurrence of HO in the animal model and may well similarly predict the development of HO in the human condition. Patients exhibiting biomarkers predictive of exuberant HO formation can then be identified before the disease process begins and treated prophylactically.

Descriptors:

• *AMPUTATION
• *ASSAYING
• *GENE EXPRESSION
• *SOFT TISSUES
• ARMY PERSONNEL
• BONES
• MATHEMATICAL PREDICTION
• MILITARY MEDICINE
• MOLECULAR DYNAMICS
• MUSCULOSKELETAL SYSTEM
• ORTHOPEDICS
• PATHOPHYSIOLOGY
• PATIENTS
• PROSTHETICS
• PROTEINS
• RATS
• REGENERATION(PHYSIOLOGY)
• RESPONSE(BIOLOGY)
• TRACER STUDIES
• TRAUMA
• WOUNDS AND INJURIES

Subject Categories:

• Genetic Engineering and Molecular Biology
• Anatomy and Physiology
• Weapons Effects (Biological)

Distribution Statement:

APPROVED FOR PUBLIC RELEASE