Alternatives to Autograft Evaluated in a Rabbit Segmental Bone Defect
ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX
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Purpose This study was designed to identify strategies for treating bone defects that can be completed on the day of surgery. Methods Forty New Zealand white rabbits with unilateral rabbit radius segmental defects 15 mm were treated with commercially available scaffolds containing either demineralised bone matrix DBM or a collagenbeta-tricalcium phosphate composite Col -TCP each scaffold was combined with either bone marrow aspirate BMA or concentrated BMA cBMA. Bone regeneration was assessed through radiographic and histological analyses. Results The concentration of nucleated cells, colony-forming unit-fibroblasts and platelets were increased and haematocrit concentration decreased in cBMA as compared to BMA p0.05. Radiographic analyses of bone formation and defect bridging demonstrated significantly greater bone regeneration in the defects treated with DBM grafts as compared to Col -TCP grafts. The healing of bones treated with Col - TCP was improved when augmented with cBMA. Conclusions Scaffolds containing either DBM or Col -TCP with BMA or cBMA are effective same-day strategies available to clinicians for the treatment of bone defects the latter scaffold may be more effective if combined with cBMA.
- Anatomy and Physiology
- Medicine and Medical Research