Accession Number:

ADA621314

Title:

Development of Silicon-Coated Superparamagnetic Iron Oxide Nanoparticles for Targeted Molecular Imaging and Hyperthermic Therapy of Prostate Cancer

Descriptive Note:

Annual rept. 15 Jul 2014-14 Jul 2015

Corporate Author:

M D ANDERSON CANCER CENTER HOUSTON TX

Report Date:

2015-08-01

Pagination or Media Count:

36.0

Abstract:

The main goal of the research project is to develop and test a novel class of dual-threat theranostic nanoparticles for targeted imaging and hyperthermic therapy of prostate cancer. These particles consist of both silicon for hyperpolarized magnetic resonance imaging, MRI and superparamagnetic iron oxide for hyperthermic therapy. Preliminary results show that simple mixtures between the two particles still allow for hyperpolarized MRI to take place, albeit with a slightly broadened 29Si NMR lineshape. The first batch of particles has been completed and physically characterized tunneling electron microsopy, dispersive x-ray spectroscopy and shown a viable coupling between the silicon approximately 300 nm and iron oxide approximately 5 nm, with the iron oxide attaching to the surface of the silicon. A small-scale hyperthermia device that induces therapeutic heating in the nanoparticles has been acquired and set up. The next steps include hyperpolarizing this first batch of particles and testing their hyperthermic effect, then applying to gelatin phantoms and prostate cancer mouse models.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research
  • Atomic and Molecular Physics and Spectroscopy
  • Biomedical Instrumentation and Bioengineering

Distribution Statement:

APPROVED FOR PUBLIC RELEASE