Accession Number:

ADA621294

Title:

A SOF Damage Control Resuscitation Cocktail

Descriptive Note:

Annual rept. 15 Apr 2014-14 Apr 2015

Corporate Author:

WASHINGTON UNIV SEATTLE

Personal Author(s):

Report Date:

2015-05-01

Pagination or Media Count:

8.0

Abstract:

The goal of this project is to develop a new damage control resuscitation DCR cocktail for use by SOFs that is capable of improving survival from polytrauma in austere settings. The cocktail components include Hextend for volume resuscitation and tissue perfusion, fibrinogen concentrate for hemostasis, and tranexamic acid for hemostasis. These components are tested in a combat-relevant swine polytrauma model of hemorrhagic shock with traumatic brain injury, free internal bleeding from an aortic tear, and femur fracture. Model development and validation, and objective 1 and 2 have been initiated in year 1 with an official project start date of April 15, 2014. The project has met with one primary scientific hurdle which has been overcome by adding vasopressin to the model to encourage more bleeding. We expect completion of this project to be on time and within budget.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Stress Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE