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Chronic Stress Impairs Collateral Blood Flow Recovery in Aged Mice
ARMY CENTER FOR ENVIRONMENTAL HEALTH RESEARCH FORT DETRICK MD
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Chronic stress is associated with increased risk of cardiovascular diseases. Aging is also associated with vascular dysfunction. We hypothesize that chronic stress accelerates collateral dysfunction in old mice. Mice were subjected to either chronic social defeat CSD or chronic cold stress CCS. The CSD mice were housed in a box inside an aggressor s cage and exposed to the aggressor. The CCS group was placed in iced water. After chronic stress, mice underwent femoral artery ligation FAL and flow recovery was measured. For the CSD group, appearance and use scores of the foot and a behavioral test were performed. CSD impaired collateral flow recovery after FAL. Further, stressed mice had greater ischemic damage, impaired foot function, and altered behavior. The CCS mice also showed impaired collateral flow recovery. Chronic stress causes hind limb collateral dysfunction in old mice, a conclusion reinforced by the fact that two types of stress produced similar changes.
APPROVED FOR PUBLIC RELEASE