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Early Life Stress and Sleep Restriction as Risk Factors in PTSD: An Integrative Pre-Clinical Approach

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Annual rept. 1 Apr 2014-31 Mar 2015

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The project proposes a novel integrative preclinical approach to study risk factors for and neurobiology of post- traumatic stress etiological agent - a trauma event that triggers it, most models of concentrate on what would constitute a trauma in the studied animals. However, because the majority of people exposed to traumatic experiences actually do not develop PTSD the exposure to the traumatic experience is necessary, but not a sufficient condition to induce the disorder. We focus on both dismal Childhood adversities and proximal Sleep restriction potential risk factors, with high relevance to soldiers. The primary aims of the project are thus 1 To establish an effective animal model of PTSD that would take into consideration risk factors to the induction of trauma. 2 To examine the role of sleep restriction as an immediate risk factor in PTSD. 3 To establish the role of childhood adversity as a long-term risk factor in PTSD, particularly in association with sleep restriction. 4 To develop the model as a platform for pharmacological testing of novel targets for drug development. 5 As an additional aim once an effective animal model is established - to use in order to identify novel targets for drug development.

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  • Psychology
  • Medicine and Medical Research

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