Accession Number:

ADA620348

Title:

Prevention of Blast-Related Injuries

Descriptive Note:

Annual rept. 15 Jun 2014-14 Jun 2015

Corporate Author:

WAYNE STATE UNIV DETROIT MI

Personal Author(s):

• King, Albert I.
• Cavanaugh, John
• Yang, King
• Zhang, Liying
• Jin, Xin
• Zhu, Feng

Report Date:

2015-07-14

Pagination or Media Count:

80.0

Abstract:

This report covers work done on blast testing of live anesthetized swine and on unembalmed cadavers. A detailed histological study of blast-exposed swine brain showed that there was damage to both the axons and the neuron cell bodies in the form beta-APP immunoreactivity and other tests, suggesting that the mechanism of injury may be different from that of blunt impact. We have also developed computer models of the swine and human brain and are in the process of validating them against the acquired experimental data. It is proposed that future research concentrate on seeking injury mechanisms to brain cells caused by a pressure wave.

Descriptors:

• *BLAST
• *WOUNDS AND INJURIES
• AXONS
• BRAIN
• COMPUTERIZED SIMULATION
• ELECTROENCEPHALOGRAPHY
• FIELD TESTS
• HISTOLOGY
• MAGNETIC RESONANCE IMAGING
• MODELS
• NERVE CELLS
• OVERPRESSURE
• PREVENTION
• SWINE
• VALIDATION

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research
• Explosions

Distribution Statement:

APPROVED FOR PUBLIC RELEASE