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Effect of Multiple Simultaneous Vaccines on Polio Seroresponse and Associated Health Outcomes

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Journal article

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Administration of multiple simultaneous vaccines to infants, children, and military recruits is not uncommon. However, little research exists to examine associated serological and health effects, especially in adults. Method We retrospectively examined 416 paired serum specimens from U.S. military subjects who had received the inactivated polio vaccine IPV alone or in combination with either 1 other vaccine less than 3 groupor 4 other vaccines greater than 4 group. Each of the 2 groups was subdivided into 2 subgroups in which Tdap was present or absent. Results The greater than 4 group was associated with a higher proportion of polio seroconversions than the less than 3 group95 vs. 58, respectively, p less than 0.01. Analysis of the less than 3 subgroup that excluded Tdap vs. the greater than 4 subgroup that excluded Tdap showed no difference between them p greater than 0.1. However, the greater than 4 subgroup that included Tdap had significantly more seroconversions than either the less than 3 subgroup that excluded Tdap or the 4 subgroup that excluded Tdap p less than 0.01. Overall, at least 98 of subjects were at or above the putative level of sero protection both pre- and post-vaccination, yet at least 81 of subjects seroconverted. In an analysis of 400 of the subjects in which clinic in- and outpatient encounters were counted over the course of 1 year following vaccinations, there was no significant difference between the 2 groups p greater than 0.1. A combination of greater than 4 vaccines including IPV appeared to have an immune potentiation effect on polio seroconversion, and Tdap in particular was a strong candidate for an important role. The dose of IPV we studied in our subjects, who already had a high level of seroprotection, acted as a booster. In addition, there appear to be no negative health consequences from receiving few versus more multiple simultaneous vaccinations.

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  • Anatomy and Physiology
  • Medicine and Medical Research
  • Pharmacology

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