Accession Number:

ADA618680

Title:

Combat Veterans with Comorbid PTSD and Mild TBI Exhibit a Greater Inhibitory Processing ERP from the Dorsal Anterior Cingulate Cortex

Descriptive Note:

Journal article

Corporate Author:

NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA

Report Date:

2014-08-08

Pagination or Media Count:

11.0

Abstract:

Posttraumatic stress disorder PTSD is common among combat personnel with mild traumatic brain injury mTBI. While patients with either PTSD or mTBI share abnormal activation of multiple frontal brain areas, anterior cingulate cortexACC activity during inhibitory processing may be particularly affected by PTSD. To further test this hypothesis, we recorded electroencephalography from 32 combat veterans with mTBI-17 of whom were also comorbid for PTSD mTBI-PTSD and 15 without PTSD mTBI-only. Subjects performed the Stop Task, a validated inhibitory control task requiring inhibition of initiated motor responses. We observed larger inhibitory processing event related potential ERP in veterans with mTBIPTSD, including greater N200 negativity. Furthermore, greater N200 negativity correlated with greater PTSD severity. This correlation was most dependent on contributions from the dorsal ACC. Support vector machine analysis demonstrated that N200 and P300 amplitudes objectively classified veterans into mTBI-only or mTBI-PTSD groups with 79.4 accuracy. Our results support a model where, in combat veterans with mTBI, larger ERPs from cingulate areas are associated with greater PTSD severity and likely related to difficulty controlling ongoing brain processes, including trauma-related thoughts and feelings.

Subject Categories:

  • Psychology
  • Medicine and Medical Research
  • Stress Physiology
  • Military Forces and Organizations

Distribution Statement:

APPROVED FOR PUBLIC RELEASE