Inherited Retinal Degenerative Disease Clinical Trials Network
Final rept. 30 Sep 2011-29 Sep 2014
FOUNDATION FIGHTING BLINDNESS CLIINICAL RESEARCH INST COLUMB IA MD
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The Foundation Fighting Blindness Clinical Research Institute FFB CRI formerly National Neurovision Research Institute NNRI the clinical arm of the Foundation Fighting Blindness FFB, established the National Eye Evaluation Research NEER Network, composed of collaborative group of five Clinical Treatment and Evaluation Center CTECs. The intent of this Network was to advance the science of therapeutic and preventive interventions for inherited orphan retinal degenerative diseases and dry age-related macular degeneration AMD through the conduct of clinical trials and other clinically relevant research. The scope of research carried out encompassed i a Phase II clinical trial to evaluate the safety and efficacy of new therapeutic and preventive approaches, by repurposing an FDA-approved small molecule drug ii natural history studies to develop standardized criteria to define disease stage, severity and progression iii observational studies to enhance understanding of the natural history of these diseases for different genotypes and phenotypes and iv evaluations of the reliability and validity of different available treatment outcomes measures to determine those that are most appropriate for various genotypes and phenotypes as well as for specific interventions.
- Anatomy and Physiology
- Medicine and Medical Research