Accession Number:

ADA618096

Title:

Comparison of the Effectiveness of Trivalent Inactivated Influenza Vaccine and Live, Attenuated Influenza Vaccine in Preventing Influenza-Like Illness among US Service Members, 2006-2009

Descriptive Note:

Journal article

Corporate Author:

NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA

Report Date:

2012-11-26

Pagination or Media Count:

11.0

Abstract:

Influenza is a significant cause of morbidity, and vaccination is the preferred preventive strategy. Data regarding the preferred influenza vaccine type among adults are limited. The effectiveness of 2 currently available influenza vaccines live, attenuated influenza vaccine LAIV versus trivalent inactivated influenza vaccine TIV in preventing influenza-like illness ILI were compared among US military members aged 18 49 years during 3 consecutive influenza seasons 2006 2009. ILI, influenza, and pneumonia events post-vaccination were compared between vaccine types using Cox proportional hazard models adjusted for sociodemographic factors, occupation, and geographic area. A total of 41,670 vaccination events were evaluated, including 28,929 during 2 well-matched seasons 2006 2007 and 2008 2009 LAIV n 22,734, TIV n 6195 and 12,741 during a poorly matched season 2007 2008 LAIV n 9447 TIV n 3294. ILI incidence rates for LAIV and TIV were 139 and 127 cases per 1000 person-seasons for the well-matched seasons, and 150 and 165 respectively, for the poorly matched season. In the multivariable models, there were no differences in ILI events by vaccine type well-matched seasons hazard ratio HR, 0.97 95 confidence interval CI, 0.90 1.06 poorly matched HR, 1.00 95 CI, 0.90 1.11. There were also no differences in influenza andor pneumonia events by vaccine group. Between 2006 2009, TIV and LAIV had similar effectiveness in preventing ILI and influenzapneumonia events among healthy adults

Subject Categories:

  • Medicine and Medical Research
  • Microbiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE