Competitive Endogenous RNAs in Prostate Cancer
Final rept. 1 Nov 2013-31 Oct 2014
MISSISSIPPI UNIV MEDICAL CENTER JACKSON
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The human genome actively transcribes a large amount of non-coding genes, including microRNA and long noncoding RNAs lncRNAs. Compared to well-known microRNAs, lncRNAs are poorly characterized. However, emerging evidence suggests that lncRNAs may be dysregulated in prostate cancer, but their role in prostate cancer remains elusive. We hypothesize that prostate cancer may exploit this mechanism to promote tumor progression and metastasis, and therapy resistance. Thus, overall goal of this application is to determine whether lncRNAs function as competitive endogenous RNAs CeRNAs which are capable of sequestering microRNAs to regulate RNA transcripts. A better understanding of how microRNAs are dysregulated in prostate cancer may help biomarker discovery, ultimately developing a better strategy for prostate cancer treatment.
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